FIGURE 1.

Cerebral endothelial transcriptome in CAA/AD mouse model and age‐matched WT mouse. (a) The expression of markers specific to different brain cells. Data were from three microarray samples in each group, same in the following Figures 1–5 unless otherwise specified. (b) Heatmap of differentially expressed genes in Tg and WT mouse brain endothelium. The average gene expression was determined for each group and was subjected to hierarchical clustering analysis. (c) Principal component analysis of the endothelial transcriptome in Tg and WT mice. (d) The correlation of gene expression change and (e) the extent of gene expression change between Tg and WT mouse brain endothelium. Fold change of gene expression in 9‐month‐old brain versus 4‐month‐old brain was determined respectively for Tg and WT mice. (f) Endothelial expression of Lrp1 in Tg and WT mice. (g) Immunohistochemistry staining of Lrp1 in Tg and WT mouse brain cortex, the same as used for transcriptome analysis. (h) Relative intensity of Lrp1 staining (n = 3 per group). Data are presented as mean ± SD. *p < 0.05