FIGURE 3.

Impaired neurovascular coupling with vascular Aβ accumulation. The expression change of (a) neurotransmitter receptors and (b) voltage‐gated calcium channel and Ca/calmodulin‐dependent protein kinases in Tg and WT mouse brain endothelium. Each dot represents a specific gene. The fold change of each gene in 9‐month‐old brain versus 4‐month‐old brain was determined respectively for Tg and WT mice. (c) Heatmap of cell adhesion molecules and cell junction molecules in Tg and WT mouse brain endothelium. (d) RT‐PCR analysis of Gria2, Gabbr1, Cacnb3, and Cacnb4 expression in HBMEC treated by Aβ40 versus vehicle (n = 5). Data are presented as mean ± SD. *p < 0.05