FIGURE 1.

Overexpression of p300 alleviates IDD. (a) p300 expression in clinical NP tissues of healthy controls and patients with IDD as determined by RT‐qPCR (n = 58). *** p < 0.001 vs. healthy controls. (b) p300 protein expression in clinical NP tissues of healthy controls and patients with IDD as determined by Western blot assay. *** p < 0.001 vs. healthy controls. (c) p300 expression in human NPCs as determined by RT‐qPCR. *** p < 0.01 vs. controls. **** p < 0.001 vs. NPC + oe‐NC. (d) The protein expression of p300 in NPCs as determined by Western blot assay. *** p < 0.001 vs. controls. **** p < 0.0001 vs. NPC + oe‐NC. (e) The number of proliferating cells in cultured NPCs as observed by EdU assay. ** p < 0.01 vs. controls. **** p < 0.0001 vs. NPC + oe‐NC. (f) The proportion of apoptotic cells in cultured NPCs. ** p < 0.01 vs. controls