FIGURE 1.

Aging clocks are targetable. (a) With age, the methylome undergoes significant changes characterized by aberrant hypermethylation and hypomethylation. These age‐associated epigenetic changes serve as the basis for epigenetic aging clocks that are thought to measure biological age. (b) Existing evidence suggests that aging clocks are malleable and can be slowed or reversed in response to various interventions, such as caloric restriction, a plant‐based diet, drugs, or lifestyle change involving physical activity