Table 2.
Effects of a 180 mg loading dose followed by 90 mg maintenance dose of Brilique ® versus Ticaloguard ® on ADP aggregation test of healthy volunteers at different time intervals
| Groups | % ADP aggregation | |||||
|---|---|---|---|---|---|---|
| Baseline | 1 h after LD | 3 h after LD | At day 4, reaching Css | 12 h after drug stop | A day after drug stop | |
| Brili group (n = 14) | 69 (48–81) | 3 (0–13) | 7.5 (0–87) | 8 (1–33) | 17.5 (0–36) | 23 (0–48) |
|
Tica group (n = 15) |
75 (48–85) | 6 (0–80) | 4 (0–88) | 22 (0–29) | 17 (5–35) | 31 (10–75) |
| p-value | 0.06 | 0.067 | 0.721 | 0.189 | 0.844 | 0.169 |
Data are presented as median (range)
Abbreviation: Brili Brilique®, Tica Ticaloguard®, ADP Adenosine diphosphate, LD Loading dose, hr Hour, Css Steady state concentration. P: Non-significant by independent-sample Mann–Whitney U test