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. 2022 Aug 3;9:959956. doi: 10.3389/fmolb.2022.959956

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Copyright © 2022 Roca-Martinez, Lazar, Gavalda-Garcia, Bickel, Pancsa, Dixit, Tzavella, Ramasamy, Sanchez-Fornaris, Grau and Vranken.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Categorization of deleterious (yellow) and benign (green) mutations from the “canonical_mut” dataset classified as disordered, ordered, and ambiguous based on models 1 [(A), top left], 2 [(B), top middle], and 3 [(C), top right], respectively. The distributions were normalized by the total number of assigned ordered, disordered and ambiguous residues in the dataset. Categorization of germline (blue) and somatic (red) mutations from the “germline_somatic_deleterious” dataset classified as disordered, ordered, and ambiguous based on models 1 [(D), bottom left], 2 [(E), bottom middle], and 3 [(F), bottom right], respectively. The distributions were normalized by the total number of assigned ordered, disordered and ambiguous residues in the dataset and the number of somatic/germline ratios for better comparison.