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. 2022 Aug 3;14:916971. doi: 10.3389/fnagi.2022.916971

Table 7.

Common-used visual cues and auditory stimulation for PD gait intervention.

Selected study Visual cues Subjects Gait improvement
Lebold and Almeida (2011) Parallel lines (optical flow) 22 PD patients Increased step length
Vitório et al. (2014) Parallel lines (white stripes) 19 PD patients Increased step length
Lee et al. (2012) Parallel lines (white stripes) 15 PD w/ FOG and 10 PD w/o FOG Improve gait kinematics significantly of PD with FOG
Schlick et al. (2016) Footprint 12 PD w/ treadmill Improved gait speed and stride length
Gómez-Jordana et al. (2018) Footprint (VR) 12 PD patients Reduced variation of step length, cadence, and velocity
Barthel et al. (2018) Laser shoes 21 PD patients Reduced number and time of FOG
Tang et al. (2019) Laser cues 34 PD w/ FOG Improved spatiotemporal parameters and Improved ROM and power generation of ankle/hip joints
Selected study Auditory Subjects Gait improvement
Thaut et al. (1996) RAS @3 rates 15 PD patients Improved gait velocity, stride length, cadence and timing of EMG patterns
Hausdorff et al. (2007) RAS @2 rates 29 PD patients Increased gait speed, stride length, swing time; Reduced variability
Mazilu et al. (2015) RAS when FOG 5 PD patients Decreased FoG duration and number
Bailey et al. (2018) RAS + PT 15 PD patients Reduced asymmetry of EMG patterns
Erra et al. (2019) RAS @3 rates 30 PD patients (on and off medication) Improved GPDI using RAS with 110% of the preferred walking freq
Hove et al. (2012) Interactive RAS 12 PD patients Improved fractal scaling to healthy 1/f level against fixed-tempo RAS
Pau et al. (2016) Personalized pace of RAS 26 PD patients Significant reduction of gait profile score and gait variable score
Ginis et al. (2016) Verbal feedback 20 PD Gait and balance improved after 6-week training
Ginis et al. (2017) 4 RAS inputs 15 PD w/ FOG and 13 PD w/o FOG Freezer showed stable gait under continuous cueing, but preferred intelligent feedback
(Murgia et al., 2018) Personalized footstep sound and metronome 32 PD patients Impovements on two RAS groups are equivalent
Marmelat et al. (2020) RAS w/ fractal step-to-beat 15 PD patients Synchronize well with fractal RAS with a 1:1 step-to-beat metronome

The number of subjects indicates the one with visual cues or auditory stimulation. VR, Virtual Reality; ROM, Range of Motion; RAS, Rhythmic Auditory Stimulation; GDPI, gait phases quality index; freq, Frequency; FOG, Freezing of Gait; PT, Physical Therapy.