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. 2022 Aug 3;16:960026. doi: 10.3389/fnins.2022.960026

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Copyright © 2022 Hao, Ding, Zhang, Yang, Zhao, Zhao, Li and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Results of the Morris water maze (MWM) tests in each group (n = 10, mean ± SD). (A,B) Comparison between the swimming speed and escape latency of all groups in the hidden platform trial. (C) Comparison between the platform crossover numbers of all groups in the probe trial. A two-way analysis of variance (ANOVA) with repeated measures, followed by the LSD multiple-range test, was used with an exception when comparing the platform crossover numbers, which was analyzed by using the Kruskal–Wallis test. LSD-t and chi-square are presented in Supplementary Tables 1, 2. ^★P < 0.01 or P < 0.05 compared with the C57BL/6 control (Cc) group, ^▲P < 0.01 or P < 0.05 compared with the APP/PS1 control (Ac) group, ^■P < 0.01 or P < 0.05 compared with the APP/PS1 antibiotic + manual acupuncture (Aa) group. (D) Swimming trace of all groups.