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. 2022 Aug 3;16:960026. doi: 10.3389/fnins.2022.960026

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Copyright © 2022 Hao, Ding, Zhang, Yang, Zhao, Zhao, Li and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Results of the 16S rRNA in each group (n = 10, mean ± SD). (A) Rank abundance curves in the APP/PS1 antibiotic + manual acupuncture (Aa) group on day 1 (before antibiotic pretreatment, Aa 1) and day 7 (after antibiotic pretreatment, Aa 2). (B) α-Diversity analysis of fecal microbiota by the Sobs index. (C) β-Diversity analysis of fecal microbiota by NMDS. (D–F) Microbial relative abundance at the phylum and genus levels. The Kruskal–Wallis test was used. Chi-square was presented in Supplementary Tables 2, 3 ^★P < 0.01 or P < 0.05 compared with the C57BL/6 control (Cc) group, ^▲P < 0.01 or P < 0.05 compared with the APP/PS1 control (Ac) group, ^■P < 0.01 or P < 0.05 compared with the APP/PS1 antibiotic + manual acupuncture (Aa) group.