TABLE 4.

The trend and function of phosphatidylserine (PS) in central nervous system (CNS) disease.

Disease	Trend of PS		Function of PS	PS improves disease
	Patient	Animal model
AD	Inconsistent	Inconsistent	Increase dendritic spine, increase acetylcholine, inhibit the microglial activation and tau hyperphosphorylation	Yes
PD	Up	Up	Initiate and enhance aggregation of α-Syn, function as carrier to deliver other drugs	Yes
MDD	Up	Up	Blunt the activation of hypothalamus pituitary adrenal axis, attenuate the cytotoxicity of corticosterone	Yes
Stroke	No data	Down	Reduced PS decrease the activity of PKC, PS liposomes inhibit inflammation	No data
ASD	down	No data	No data	No data
ADHD	No data	No data	No data	Yes
Schizophrenia	inconsistent	No data	No data	No data
SCI	No data	Down	No data	No data