Table 3.
Age Stratified, Fine & Gray method for proportional hazard models presented as Sub-Distribution Hazard ratios (SHR) and 95% confidence intervals (CI) for the association between allostatic load and cancer death accounting for competing risks of all-cause mortality, among 41,218 NHANES participants with 2,559 cancer-related deaths, and 8,988 competing deaths.
| No.Cancer Deaths (%)a | No.All-cause Deaths (%)a | Mean Survival Months (SE)b | Sub-Distribution Hazard Ratio (SHR) and 95% Confidence Interval (CI)b | ||
|---|---|---|---|---|---|
| Age < 40 years (N = 16,319) | |||||
| Risk among All Adults (N = 16,319) | |||||
| Allostatic Load | |||||
| Low Allostatic Load | 109 (0.92) | 360 (2.48) | 354.89 (0.21) | 1.00 (Referent) | |
| High Allostatic Load | 80 (1.91) | 302 (6.44) | 356.23 (0.55) | 1.80 (1.35–2.41) | |
| Risk among Non-Hispanic White Adults (N = 5,877) | |||||
| Allostatic Load | |||||
| Low Allostatic Load | 47 (1.04) | 113 (2.52) | 354.48 (0.39) | 1.00 (Referent) | |
| High Allostatic Load | 25 (2.26) | 70 (6.30) | 355.34 (1.18) | 1.95 (1.22–3.12) | |
| Risk among Non-Hispanic Black Adults (N = 4,209) | |||||
| Allostatic Load | |||||
| Low Allostatic Load | 30 (1.00) | 112 (3.05) | 347.68 (0.46) | 1.00 (Referent) | |
| High Allostatic Load | 41 (2.11) | 140 (7.98) | 340.38 (0.95) | 2.06 (1.27–3.34) | |
| Risk among Hispanic Adults (N = 5,462) | |||||
| Allostatic Load | |||||
| Low Allostatic Load | 30 (0.58) | 121 (1.93) | 348.46 (0.30) | 1.00 (Referent) | |
| High Allostatic Load | 13 (0.77) | 82 (4.64) | 320.98 (0.62) | 1.36 (0.70–2.62) | |
| Age 40–59 years (N = 11,830) | |||||
| Risk among All Adults (N = 11,830) | |||||
| Allostatic Load | |||||
| Low Allostatic Load | 254 (3.81) | 401 (5.78) | 355.24 (0.98) | 1.00 (Referent) | |
| High Allostatic Load | 463 (6.79) | 1110 (14.66) | 344.99 (0.94) | 1.19 (1.01–1.39) | |
| Risk among Non-Hispanic White Adults (N = 5,486) | |||||
| Allostatic Load | |||||
| Low Allostatic Load | 132 (3.77) | 207 (5.78) | 338.99 (1.14) | 1.00 (Referent) | |
| High Allostatic Load | 219 (7.24) | 446 (14.68) | 330.17 (1.49) | 1.38 (1.11–1.73) | |
| Risk among Non-Hispanic Black Adults (N = 2,664) | |||||
| Allostatic Load | |||||
| Low Allostatic Load | 69 (6.81) | 86 (9.10) | 299.38 (2.22) | 1.00 (Referent) | |
| High Allostatic Load | 146 (6.49) | 374 (16.82) | 331.43 (1.67) | 0.81 (0.61–1.10) | |
| Risk among Hispanic Adults (N = 3,177) | |||||
| Allostatic Load | |||||
| Low Allostatic Load | 49 (2.77) | 91 (3.44) | 358.96 (1.74) | 1.00 (Referent) | |
| High Allostatic Load | 82 (3.17) | 255 (11.39) | 352.27 (1.49) | 1.11 (0.77–1.59) | |
| Age ≥ 60 years (N = 13,069) | |||||
| Risk among All Adults (N = 13,069) | |||||
| Allostatic Load | |||||
| Low Allostatic Load | 422 (10.87) | 1554 (38.77) | 310.41 (2.39) | 1.00 (Referent) | |
| High Allostatic Load | 1231 (12.23) | 5261 (53.12) | 300.99 (1.49) | 1.05 (0.94–1.19) | |
| Risk among Non-Hispanic White Adults (N = 7,715) | |||||
| Allostatic Load | |||||
| Low Allostatic Load | 274 (10.90) | 1104 (39.79) | 293.36 (2.79) | 1.00 (Referent) | |
| High Allostatic Load | 713 (12.50) | 3267 (54.51) | 296.12 (2.20) | 1.11 (0.96–1.28) | |
| Risk among Non-Hispanic Black Adults (N = 2,222) | |||||
| Allostatic Load | |||||
| Low Allostatic Load | 57 (13.92) | 133 (33.94) | 264.75 (5.48) | 1.00 (Referent) | |
| High Allostatic Load | 273 (13.55) | 986 (51.46) | 283.93 (2.92) | 0.89 (0.66–1.21) | |
| Risk among Hispanic Adults (N = 2,760) | |||||
| Allostatic Load | |||||
| Low Allostatic Load | 84 (10.77) | 270 (29.60) | 319.92 (4.18) | 1.00 (Referent) | |
| High Allostatic Load | 228 (10.10) | 884 (38.86) | 303.62 (2.56) | 1.07 (0.83–1.38) | |
Model is adjusted for time period, sociodemographic factors, and health factors including current smoker status, having ever diagnosed with cancer, ever diagnosed with congestive heart failure, ever diagnosed with heart attack.
a Percentages are weighted.
b Models are un-weighted.