Skip to main content
. 2022 Jul 29;64:101556. doi: 10.1016/j.molmet.2022.101556

Figure 5.

Figure 5

Tryptophan and light regulate Timeless expression in the suprachiasmatic nucleus. A-B. Gene expression of core clock genes in the SCN of mice housed under light/dark cycles (A) or constant darkness (B). C. Table of the top 5 genes rhythmic Ctrl but not -Trp in DD. D. Gene expression of Timeless in the SCN in constant darkness over the circadian 24-hr period. E. Timeless expression in the SCN at CT17 of mice housed in constant darkness (DD) or ZT1 in mice exposed to a 1-hr light pulse at CT16 after being housed in constant darkness for three weeks and fed a tryptophan depleted diet (-Trp) for the two last weeks and compared to mice fed nitrogen matched chow (Ctrl). Statistics were analyzed by two-way ANOVA and subsequently tested with Fischer's least significant difference test. ∗P < 0.05. Data are mean ± s.e. N = 3 for mice housed in DD and N = 6 for mice exposed to a light pulse.