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Structures of kinases switching between an active C-helix in conformation and an inactive C-helix out conformation. A, structure of active CDK2–cyclinA in complex with substrate (Protein Data Bank [PDB] entry: 1QMZ) (110). B, structure of inactive CDK2 (PDB entry: 1HCL) (111). C, structure of inactive NEK7 (PDB entry: 2WQN) (25). The side chains of the four R-spine residues are shown as solid green spheres.
