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. 2022 Jul 10;298(8):102247. doi: 10.1016/j.jbc.2022.102247

Figure 7.

Figure 7

Type IV inhibitors bind to allosteric pockets distant from the ATP site.Left, crystal structure of ABL1 in complex with imatinib (magenta) and GNF-2 (black) (Protein Data Bank [PDB] entry: 3K5V) (89). Right, crystal structure of Aurora-A in complex with ADP (red) and compound 18 (black) (PDB entry: 5OS5) (96). Note that the Y-pocket of Aurora-A is structurally equivalent to the PIF pocket of AGC kinases such as PDK1. PDK1, phosphoinositide-dependent protein kinase 1; PIF, PDK1-interacting fragment.