Table 1. Baseline Characteristics of 427 Patients in the Individual-Patient Data Meta-analysis.
| Characteristic | Extent of resection, No. (%) | P value | ||
|---|---|---|---|---|
| GTR (n = 124) | STR (n = 187) | Biopsy (n = 116) | ||
| Age at diagnosis, mean (SD), y | 7.3 (5.9) | 9.7 (5.7) | 10.8 (5.7) | <.001a |
| Sex (n = 317) | ||||
| Female | 35 (40.7) | 67 (48.6) | 46 (49.5) | .42 |
| Male | 51 (59.3) | 71 (51.4) | 47 (50.5) | |
| Tumor location (n = 349) | ||||
| Hemispheric | 50 (46.3) | 59 (39.9) | 24 (25.8) | <.001a |
| Midline | 23 (21.3) | 58 (39.2) | 51 (54.8) | |
| Infratentorial | 35 (32.4) | 31 (20.9) | 18 (19.4) | |
| Tumor histologic grade (n = 427) | ||||
| WHO grade III | 40 (32.3) | 73 (39.0) | 68 (58.6) | <.001a |
| WHO grade IV | 84 (67.7) | 114 (61.0) | 48 (41.4) | |
| Adjuvant treatment (n = 421) | ||||
| Radiotherapy with chemotherapy | 72 (59.0) | 130 (70.7) | 88 (76.5) | <.001a |
| Radiotherapy alone | 7 (5.7) | 22 (12.0) | 12 (10.4) | |
| Chemotherapy alone | 34 (27.9) | 29 (15.8) | 13 (11.3) | |
| None | 9 (7.4) | 3 (1.6) | 2 (1.7) | |
| Overall survival, median (95% CI), mob | 27.1 (41.7-60.3) | 13.2 (12.0-17.7) | 14.0 (11.4-15.6) | <.001a |
Abbreviations: GTR, gross total resection; STR, subtotal resection; WHO, World Health Organization Classification of Tumors of the Central Nervous System.
a
P < .05 indicates statistically significant difference in characteristics between groups.
b
Overall survival is reported as median (95% CI), both of which were derived from Kaplan-Meier analysis.