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. Author manuscript; available in PMC: 2022 Aug 17.
Published in final edited form as: J Am Acad Child Adolesc Psychiatry. 2016 Nov 2;56(1):67–78. doi: 10.1016/j.jaac.2016.10.009

FIGURE 1.

FIGURE 1

Identifying neural markers associated with risk, resilience, or disorder sequelae. Note: Having all three of these groups (high- and low-risk youths and those with bipolar disorder [BD]) is necessary to disentangle these markers. Brain activation patterns (a) shared by high-risk (HR) and BD (but not low-risk [LR]) youths (HR+BD≠LR) may indicate potential risk endophenotypes; (b) unique to high-risk youths (HR≠BD+LR) may indicate potential resilience markers; (c) and unique to youths with BD (BD≠HR+LR) may indicate potential disorder sequelae.