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. 2022 Jul 16;5(8):3766–3777. doi: 10.1021/acsabm.2c00319

Table 2. Experimental Conditions, Emulsion Formulations, and Droplet/Particle Sizes for Different Sample Runs.

    S1 S2 S3 S4 S5 S6 S7 S8 S9
nominal channel depth, DMC (μm) 5 4 2 4 4 4 4 4 4
dispersed phase composition (wt %) SRL 1.32 1.32 1.32 1.32 1.64 1.76 1.80 1.84 2.25
  PLGA 2.68 2.68 2.68 2.68 2.34 2.24 2.20 2.16 2.25
  IPAc 72.00 72.00 72.00 72.00 72.00 72.00 72.00 72.00 71.63
  DCM 24.00 24.00 24.00 24.00 24.00 24.00 24.00 24.00 23.88
CP composition (wt %) PVA 1.50 1.50 1.50 1.50 1.50 1.00 1.00 1.00 1.00
  Milli-Q water 98.50 98.50 98.50 98.50 98.50 99.00 99.00 99.00 99.00
drug loading (wt %) 33 33 33 33 42 44 45 46 50
total solids in the dispersed phase (wt %) 4 4 4 4 4 4 4 4 5
droplet production time 48 h 24 h 24 h 24 h 48 h 24 h 24 h 24 h 24 h
flowrate (mL/h) dispersed phase 0.15 0.03 0.01 0.03 0.05 0.02 0.05 0.02  
  CP 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
mean droplet size (μm) 23.5 13.8 5.2 13.8 13.8 13.8 13.6 13.8 13.5
CV of droplet sizes (%) 3.0 2.5 3.5 2.5 3.0 2.6 2.0 2.5 2.4
predicted particle size (μm) 7.0 4.1 1.5 4.1 4.2 4.2 4.3 4.3 4.5
mean particle size (μm) 8.5 3.8 1.8 4.2 4.0 4.2 4.2 4.2 4.3
CV of particle sizes (%) 4.5 5.2 6.0 5.2 4.1 4.3 5.1 4.8 4.6