Table 2. Experimental Conditions, Emulsion Formulations, and Droplet/Particle Sizes for Different Sample Runs.
| S1 | S2 | S3 | S4 | S5 | S6 | S7 | S8 | S9 | ||
|---|---|---|---|---|---|---|---|---|---|---|
| nominal channel depth, DMC (μm) | 5 | 4 | 2 | 4 | 4 | 4 | 4 | 4 | 4 | |
| dispersed phase composition (wt %) | SRL | 1.32 | 1.32 | 1.32 | 1.32 | 1.64 | 1.76 | 1.80 | 1.84 | 2.25 |
| PLGA | 2.68 | 2.68 | 2.68 | 2.68 | 2.34 | 2.24 | 2.20 | 2.16 | 2.25 | |
| IPAc | 72.00 | 72.00 | 72.00 | 72.00 | 72.00 | 72.00 | 72.00 | 72.00 | 71.63 | |
| DCM | 24.00 | 24.00 | 24.00 | 24.00 | 24.00 | 24.00 | 24.00 | 24.00 | 23.88 | |
| CP composition (wt %) | PVA | 1.50 | 1.50 | 1.50 | 1.50 | 1.50 | 1.00 | 1.00 | 1.00 | 1.00 |
| Milli-Q water | 98.50 | 98.50 | 98.50 | 98.50 | 98.50 | 99.00 | 99.00 | 99.00 | 99.00 | |
| drug loading (wt %) | 33 | 33 | 33 | 33 | 42 | 44 | 45 | 46 | 50 | |
| total solids in the dispersed phase (wt %) | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 5 | |
| droplet production time | 48 h | 24 h | 24 h | 24 h | 48 h | 24 h | 24 h | 24 h | 24 h | |
| flowrate (mL/h) | dispersed phase | 0.15 | 0.03 | 0.01 | 0.03 | 0.05 | 0.02 | 0.05 | 0.02 | |
| CP | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |
| mean droplet size (μm) | 23.5 | 13.8 | 5.2 | 13.8 | 13.8 | 13.8 | 13.6 | 13.8 | 13.5 | |
| CV of droplet sizes (%) | 3.0 | 2.5 | 3.5 | 2.5 | 3.0 | 2.6 | 2.0 | 2.5 | 2.4 | |
| predicted particle size (μm) | 7.0 | 4.1 | 1.5 | 4.1 | 4.2 | 4.2 | 4.3 | 4.3 | 4.5 | |
| mean particle size (μm) | 8.5 | 3.8 | 1.8 | 4.2 | 4.0 | 4.2 | 4.2 | 4.2 | 4.3 | |
| CV of particle sizes (%) | 4.5 | 5.2 | 6.0 | 5.2 | 4.1 | 4.3 | 5.1 | 4.8 | 4.6 | |