Skip to main content
. 2022 Jul 11;5(8):3608–3622. doi: 10.1021/acsabm.2c00384

Table 3. Incorporation of Different Ions in Melt Derived BBG Scaffolds for Soft Tissue Engineering Applications.

composition dopant findings
60B2O3–36CaO–(4 – x)P2O5xAg2O (in mol %) powder 0, 0.3, 0.5, 1 mol % silver ions Silver doped glass inhibited bacterial growth while undoped glass did not show such effect. All groups were nontoxic to fibroblasts and kerotinocytes. 0.3 and 0.5 mol % silver ion doped group reduced wound area39
13-93B3 fibers 0.4% copper oxide and 1% zinc oxide ions Human skin fibroblast cells had high cell viability, growth, and migration ability30
13-93B3 powder 1% zinc, 3% copper oxide ions Dendritic cell viability decreased with increase of copper oxide concentration to 3% and zinc ion concentration to 10%. Zinc and copper oxide ions avoid bacterial growth14
13-93B3 fiber 0.5, 1.0, and 3.0 wt % copper oxide ions % cell viability of HUVEC and fibroblast cells increased up to 3% copper oxide ions over 7 days. Copper oxide ions enhanced wound repair capability44
13-93B3 scaffold 1, 3, 5 wt % cerium ions, 1 and 3 wt % vanadium, 1 and 5 wt % gallium ions Cerium ions enhance angiogenesis while vanadium and gallium ions showed no such effect43
(52 – x)B2O–-16ZnO–14Na2O–CaO–P2O5xGa2O3 (in wt %) powder 2.5, 5, 10, and 15 wt % gallium ions Gallium ions increased antibacterial effect40
13-93B3 powder Cobalt, iron, gallium, iodine, strontium, and zinc ions Priming with ion doped BBG increased the homing capacity of adipose stem cells79