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. 2022 Aug 3;12:967000. doi: 10.3389/fonc.2022.967000

Figure 4.

Figure 4

LncRNA SCAMP1 interacts with and regulates miR-26a-5p in osteosarcoma cells. (A): Potential binding sites between miR-26a-5p and lncRNA SCAMP1. (B): Dual luciferase reporter assays showed that miR-26a interacted with lncRNA SAMP1. miR-26a-5p modulation regulated luciferase activity in SCAMP1 wild-type group. (C): RT-PCR data showed that miR-26a inhibitors decreased the expression of miR-26a-5p in MG63 cells, while miR-26a mimic transfection increased the miR-26a-5p expression levels in U2OS cells. (D): RT-PCR data showed that upregulation of SCAMP1 suppressed the expression of miR-26a-5p in MG63 cells, while sh-SCAMP1 increased miR-26a-5p expression in U2OS cells. SCAMP1-WT: SCAMP1 wild type; SCAMP1-MUT: SCAMP1 mutant. **P < 0.01; ***P < 0.001 vs control group; ns, no significance.