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. 2022 Aug 3;12:967000. doi: 10.3389/fonc.2022.967000

Figure 7.

Figure 7

LncRNA SCAMP1 increases cell malignant progression via miR-26a/ZEB2 axis. (A): CCK8 assays data showed that upregulation of ZEB2 abrogated miR-26a-5p-induced inhibition of cell viability in MG63 cells. SCAMP1 overexpression elevated cell viability, which was blocked by downregulation of ZEB2 in MG63 cells. (B): Colony formation data showed that ZEB2 cDNA transfection increased colony formation of MG63 cells, which was abrogated by miR-26a mimics transfection. SCAMP1 upregulation elevated colony formation of MG63 cells, which was blocked by sh-ZEB2 transfection. (C): Transwell invasion assay data showed that upregulation of ZEB2 abrogated miR-26a-5p-induced suppression of cell invasion in MG63 cells. SCAMP1 overexpression elevated cell invasion, which was reduced by downregulation of ZEB2 in MG63 cells. Right panel: quantitative data is shown for invasion assay of left panel. (D): Wound healing assays showed that ZEB2 cDNA transfection increased migrative ability of MG63 cells, which was abrogated by miR-26a mimics transfection. LncRNA SCAMP1 upregulation elevated migrative ability of MG63 cells, which was blocked by sh-ZEB2 transfection. **p<0.01 vs. control group; $p<0.01 vs. pZEB2 group; #p<0.01 vs. control group; &p<0.01 vs. SCAMP1 group. ; *p < 0.05 vs control group.