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The circRNA/VEGF signaling axis in CRC. VEGF binds to tyrosine kinase cell receptors (VEGFR1-3) to activate VEGF signaling in endothelial cells. The activation of VEGF signaling can not only induce the protein expression of SRC kinase and FAK Focal adhesion kinase, but also trigger PI3K/AKT and MAPK signal transduction. Finally, it regulates the process of angiogenesis, proliferation, migration, and survival.
