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. 2022 Aug 3;12:949656. doi: 10.3389/fonc.2022.949656

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Copyright © 2022 Wang, Cheng, Wu and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The circRNA/JAK/STAT signaling axis in CRC. The binding of the cytokine to the receptor induces receptor dimers and initiates signal transduction. After JAKs are activated and phosphorylated, STATs proteins are recruited to the phosphorylated tyrosine site. STATs are also then activated and phosphorylated. Normally, STATs reside in the cytoplasm and form phosphorylated dimers when activated by upstream signals. STAT-STAT dimers are transferred from the cytoplasm to the nucleus and regulate the transcription of target genes. Finally, it affects the proliferation, differentiation, invasion, inflammation, and immune function of cancer cells.