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The circRNA/Notch signaling axis in CRC. This signaling is initiated by ligand-receptor binding between the signal-sending cell and the signal-receiving cell. The receptor-ligand interaction triggers a continuous cleavage mediated by ADAM metalloproteinase and γ-secretase, followed by the release of the intracellular domain NICD by Notch. When NICD is transferred to the nucleus, it recruits MAML and Co-A to CSL to initiate the expression of target genes.
