Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Aug 3;12:949656. doi: 10.3389/fonc.2022.949656

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Wang, Cheng, Wu and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The circRNA/Hippo/YAP signaling axis in CRC. Mst1/2 is activated by upstream NF2 and RASSF family proteins. Phosphorylated Mst1/2 and MAP4Ks transmit multiple signals to activate Lats1/2, which inhibit YAP/TAZ phosphorylation. The activated YAP/TAZ enters the nucleus and binds with the transcription factor TEADs to induce gene expression. Ultimately, it regulates cell proliferation, migration, apoptosis, and the stemness properties of CSCs.