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The circRNA/WNT/β−catenin signaling axis in CRC. The linking of WNT protein to the FZD-LRP5/6 receptor complex activates the downstream protein Disheveled. It further promoted the dissociation of GSK-3β from Axin, which inhibited the phosphorylation of β-catenin. Unphosphorylated β-catenin is transferred to the nucleus and binds to the transcription factor TCF/LEF to induce transcription of the target genes.
