Table 1.
Potential clinical application value of circRNAs in CRC.
| CircRNA | Expression | Effect | Potential application | Reference |
|---|---|---|---|---|
| Circ_3823 | Upregulated | Promote growth, metastasis, and angiogenesis | Diagnostic marker or therapeutic target | (114) |
| Circ_0004104 | Upregulated | Promote proliferation, and migration | Diagnostic and prognostic biomarker, and therapeutic target | (19) |
| Circ-MYH9 | Upregulated | Promote proliferation | Therapeutic target | (115) |
| Circ_0005963 | Upregulated | Promote glycolysis and oxaliplatin resistance | Therapeutic target of drug‐resistant patients | (117) |
| CircRNA_0001178 | Upregulated | – | Diagnosing liver metastases from CRC | (18) |
| CircRNA_0000826 | Upregulated | – | Diagnosing liver metastases from CRC | (18) |
| Circ-HERC4 | Upregulated | Promote proliferation and migration/Induce liver and lung metastasis | Prognostic biomarker and therapeutic target | (20) |
| Circ-MAPK14 | Downregulated | Block progression and metastasis | Therapeutic target | (70) |
| Circ-ITGA7 | Downregulated | Suppress growth and metastasis | Therapeutic target | (71) |
| CiRS-7 | Upregulated | Promote proliferation, migration, and invasion | Prognostic biomarker and therapeutic target | (72) |
| Circ_0008285 | Downregulated | Inhibit proliferation and migration | Therapeutic target | (79) |
| Circ-IL4R | Upregulated | Promote proliferation, migration, and invasion | Diagnostic and prognostic biomarker, and therapeutic target | (80) |
| Circ_001971 | Upregulated | Promote proliferation, invasion, and angiogenesis | Therapeutic target | (31) |
| Circ_0056618 | Upregulated | Promote proliferation, migration, and angiogenesis | Therapeutic target | (86) |
| Circ-SPARC | Upregulated | Promote proliferation and migration | Diagnostic and prognostic biomarker, and therapeutic target | (19) |
| Circ_0000372 | Upregulated | Promote proliferation, migration, and invasion | Prognostic biomarker and therapeutic target | (28) |
| Circ-NSD2 | Upregulated | Promote migration and metastasis | Prognostic biomarker and therapeutic target | (27) |
| Circ-APLP2 | Upregulated | Promote proliferation, migration, and invasion/Induce tumor growth and liver metastases | Therapeutic target | (96) |
| Circ-PPP1R12A | Upregulated | Promote proliferation, migration, and invasion | Therapeutic target | (51) |
| Circ_0128846 | Upregulated | Promote proliferation, migration, invasion, and cell cycle progression/Inhibit apoptosis | Therapeutic target | (29) |
| Circ_0106714 | Downregulated | Inhibit proliferation, migration, and invasion/Promote apoptosis | Prognostic biomarker and therapeutic target | (46) |
| Circ_0068464 | Upregulated | Promote proliferation, migration/Induce tumor growth and lung metastasis | Diagnostic biomarker and therapeutic target | (105) |
| Circ_0082182 | Upregulated | Promote proliferation, cell cycle progression, and metastasis/Inhibit apoptosis. | Diagnostic biomarker and therapeutic target | (106) |
| Circ_0026628 | Upregulated | Promote proliferation, migration, EMT, and stemness | Therapeutic target | (107) |
| Circ_0000523 | Downregulated | Inhibit proliferation/Promote apoptosis | Therapeutic target | (108) |
| Circ-MTO1 | Downregulated | Inhibit proliferation and invasion | Therapeutic target | (109) |
| Circ-PRKDC | Upregulated | Enhance 5-FU resistance | Therapeutic target of 5-FU-resistant patients | (111) |