Table 5.
The predicted vaccine constructs for NeoCoV.
| Vaccine Name | Adjuvant | Epitope count | Length | Vaccine Constructs |
|---|---|---|---|---|
| NeoCoV vaccine- 1 (Neo-1) | β-defensin | HTL (6) CTL (5) B-cell (5) |
358 | GIINTLQKYYCRVRCAVLSCLPKEEQIGKCSTRGRKCCRRKKEAAAKAKFVAAWTLKAAAGGGSVFTVVCAITLAAYGTNSGVAIYAAYSTPAQNAGYAAYWSYTGSSFYAAYHSPGKNLRYGGGSLPNEITVAKPNVLIAGPGPGTKSFNMVQAFGLRGAGPGPGSTSYYSAKPVGAYYEGPGPGTAKYTPAPGTSLHPVGGPGSTVFVPATRDSVPLHGPGPGSPDFVAFNVFHGMETGGGSTGRSVYVKFQESKPPLPPEEKKMSNMTQLSEQQIIAIIKDWNKKGNSSRGASPGPSGVGAPGGDKKNNLPPPLLSNSTGTDFKDELKKLGIGGDRTERLTQEMELSNWHHHHHH |
| NeoCoV vaccine- 2 (Neo-2) | Ribosomal protein | HTL (6) CTL (5) B-cell (5) |
438 | MAKLSTDELLKEMTLLELSDFVKKFEETFEVTAAAPVAVAAAGAAPAGAAVEAAEEQSEFDVILEAAGDKKIGVIKVVREIVSGLGLKEAKDLVDGAPKPLLEKVAKEAADEAKAKLEAAGATVTVKEAAAKAKFVAAWTLKAAAGGGSASFSVLACYAAYALSIFSAVYAAYSAFMGMSQFAAYSAFMGMSQFAAYYSTNITHLLGGGSKGKFVQIPSQCTRDPGPGPGSKCYRAMNAYPLVVTQQLYTGFQGKQILGSGPGPGLIALKMVKRQSYGTNGPGPGPKVITKKDAAAAKNKGPGPGPEPITTLNTRYVAPQGGGSKPVQLVPVSPVDHGGESNDSKKKFDSGTLSKASDWKCKVTDVKKGAVQQESDEYILTRGPLQVGKKLVSMTNHSFSVQKHVGAPANKKTNQPRGRGRNPKPRAAPNTTHHHHHH |
| NeoCoV vaccine- 3 (Neo-3) | Heparin-binding hemagglutinin | HTL (6) CTL (3) B-cell (5) |
448 | MAENPNIDDLPLAALGAADLALATVNDLIANLRERAEETRAETRTRVEERRARLTKFQEDLPEQFIELRDKFTTEELRKAAEGYLEAATNRYNELVERGEAALQRLRSQTAFEDASARAEGYVDQAVELTQEALGTVASQTRAVGERAAKLVGIELEAAAKAKFVAAWTLKAAAGGGSLLITIVLQYAAYISYAGAYSYAAYSVVTQPTHYGGGSARDISPIAVFLRNVRGPGPGFRTVVLNNKNSYRSQGPGPGGTGIAISVKPESTADGPGPGAKNILHVVGPDARAKGPGPGTGTFTVIMRPNYTIKGPGPGSGAIKLDPKNPNYNKGGGSPKKEKKQKAPKEESNDQEMAKKANAKIVTLPGNDATGYCPSVKKFFNGADISDTIPDEKQHGCSKKEEGATDAPSTFGTRNPNNDSKKNSPTTGQLWAYNFGGVPYRVHHHHHH |
| NeoCoV vaccine- 4 (Neo-4) | Ribosomal protein | HTL (6) CTL (5) B-cell (4) |
415 | MSDINKLAENLKIVEVNDLAKILKEKYGLDPSANLAIPSLPKAEILDKSKEKTSFDLILKGAGSAKLTVVKRIKDLIGLGLKESKDLVDNVPKHLKKGLSKEEAESLKKQLEEVGAEVELKEAAAKAKFVAAWTLKAAAGGGSSVTIADPGYAAYALQEVVKALAAYTMKKIYPALAAYMVYVITVKYAAYFLFATVPIYGGGSPRWYFYYTGTGPEAAGPGPGISYDIYGITGTGVFQGPGPGYVAGYKVLPPLMDVNGPGPGGTQYVYSASNHKSTAGPGPGTQYVYSASNHKSTANGPGPGIIGFHSDDGNYYCVAGGGSDLGTQYVYSASNHKSTANDAKKNYGATNKDDVVKPGGRASQQKKLLQPRTESKCPGNSNYVSYFKKESVKTPQTVPLTTGFGGEFNHHHHHH |
The sequences highlighted in bold are the pan HLA DR-binding epitope (PADRE), whereas the italics sequences are the B-cell epitopes.