Table 3.
Subgroup analysis of the associations between NLR and diabetic retinopathy
| NLR | P for interaction | |||
|---|---|---|---|---|
| < 1.76 | ≥1.76, < 2.57 | ≥2.57 | ||
| Gender | 0.2452 | |||
| Male | 1.0(ref) | 1.259 (0.922, 1.719) | 1.361 (1.005, 1.843) | |
| Female | 1.0(ref) | 1.046 (0.750, 1.458) | 1.606 (1.166, 2.213) | |
| Marital Status | 0.1623 | |||
| Married | 1.0(ref) | 1.120 (0.828, 1.515) | 1.721 (1.291, 2.294) | |
| Widowed/divorced | 1.0(ref) | 1.199 (0.820, 1.753) | 1.183 (0.809, 1.729) | |
| Never married | 1.0(ref) | 1.833 (0.872, 3.854) | 1.609 (0.747, 3.462) | |
| Age, years | 0.2286 | |||
| < 63 | 1.0(ref) | 1.293 (0.946, 1.767) | 1.823 (1.332, 2.495) | |
| ≥ 63 | 1.0(ref) | 1.103 (0.798, 1.524) | 1.278 (0.941, 1.737) | |
| SBP, mmHg | 0.4644 | |||
| < 130 | 1.0(ref) | 1.138 (0.811, 1.596) | 1.593 (1.145, 2.216) | |
| ≥ 130 | 1.0(ref) | 1.229 (0.887, 1.702) | 1.225 (0.891, 1.683) | |
| DBP, mmHg | 0.7890 | |||
| < 68 | 1.0(ref) | 1.269 (0.888, 1.812) | 1.411 (1.001, 1.988) | |
| ≥ 68 | 1.0(ref) | 1.091 (0.797, 1.493) | 1.332 (0.975, 1.819) | |
| BMI, kg/m2 | 0.1015 | |||
| < 31.2 | 1.0(ref) | 1.019 (0.735, 1.413) | 1.520 (1.112, 2.078) | |
| ≥ 31.2 | 1.0(ref) | 1.308 (0.952, 1.796) | 1.364 (0.996, 1.867) | |
| Waist circumference, cm | 0.0241* | |||
| < 107.6 | 1.0(ref) | 1.010 (0.726, 1.406) | 1.365 (0.982, 1.899) | |
| ≥ 107.6 | 1.0(ref) | 1.386 (0.991, 1.938) | 1.459 (1.054, 2.020) | |
| Hemoglobin, g/dl | 0.0085** | |||
| < 13.6 | 1.0(ref) | 1.217 (0.881, 1.679) | 1.699 (1.252, 2.304) | |
| ≥ 13.6 | 1.0(ref) | 1.198 (0.876, 1.639) | 1.352 (0.988, 1.849) | |
| PIR | 0.2918 | |||
| < 1.7 | 1.0(ref) | 1.326 (0.958, 1.835) | 1.588 (1.152, 2.190) | |
| ≥ 1.7 | 1.0(ref) | 1.120 (0.791, 1.586) | 1.540 (1.105, 2.145) | |
| TC, mg/dl | 0.8835 | |||
| < 174 | 1.0(ref) | 1.235 (0.897, 1.699) | 1.325 (0.970, 1.809) | |
| ≥ 174 | 1.0(ref) | 1.112 (0.802, 1.541) | 1.629 (1.189, 2.232) | |
| HDL, mg/dl | 0.3069 | |||
| < 46 | 1.0(ref) | 1.302 (0.946, 1.793) | 1.478 (1.077, 2.027) | |
| ≥ 46 | 1.0(ref) | 1.082 (0.781, 1.497) | 1.492 (1.095, 2.031) | |
| LDL, mg/dl | 0.9532 | |||
| < 96 | 1.0(ref) | 1.148 (0.700, 1.883) | 1.285 (0.804, 2.053) | |
| ≥ 96 | 1.0(ref) | 1.486 (0.908, 2.431) 1 | 1.595 (0.968, 2.631) | |
| Triglycerides, mg/dl | 0.6060 | |||
| < 120 | 1.0(ref) | 1.391 (0.852, 2.274) | 1.468 (0.919, 2.343) | |
| ≥ 120 | 1.0(ref) | 1.187 (0.737, 1.911) | 1.428 (0.889, 2.293) | |
| HbA1c, % | 0.4348 | |||
| < 7 | 1.0(ref) | 1.265 (0.886, 1.806) | 1.403 (0.988, 1.993) | |
| ≥ 7 | 1.0(ref) | 1.147 (0.855, 1.540) | 1.605 (1.207, 2.133) | |
| CHD | 0.4167 | |||
| Yes | 1.0(ref) | 1.325 (0.683, 2.571) | 0.930 (0.486, 1.781) | |
| No | 1.0(ref) | 1.149 (0.903, 1.463) | 1.621 (1.283, 2.047) | |
| Stroke | 0.6780 | |||
| Yes | 1.0(ref) | 1.569 (0.741, 3.320) | 2.026 (0.991, 4.141) | |
| No | 1.0(ref) | 1.151 (0.908, 1.458) | 1.446 (1.148, 1.823) | |
| HF | 0.4004 | |||
| Yes | 1.0(ref) | 1.349 (0.651, 2.796) | 1.088 (0.552, 2.145) | |
| No | 1.0(ref) | 1.148 (0.904, 1.458) | 1.513 (1.197, 1.913) | |
NLR Neutrophil to lymphocyte ratio, SBP Systolic blood pressure, DBP Diastolic blood pressure, BMI Body mass index, PIR Poverty income ratio, TC Total cholesterol, HDL High density lipoprotein, LDL Low density lipoprotein, HbA1c Glycosylated hemoglobin A1c, CHD Coronary heart disease, HF Heart failure
*P < 0.05, **P < 0.01