Table 1.
Baseline Characteristics and Biochemistry
| Subject | Age | Sex | Race | Tumor location | TIO duration | FGF23 | Phosphate | 1,25 (OH)2D | TRP | P1NP (μg/L) | C‐telopeptide (pg/mL) | Alkaline phosphatase | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Intact | C‐terminal | ||||||||||||
| Normal range/units | years | years | <52 pg/mL | <180 RU/mL | 2.5–4.5 mg/dL | 20–79 pmol/L | 85%–95% | μ/L a | pg/mL a | 35–105 U/L | |||
| 1 | 41 | M | W | C7 vertebra | 10 | 1459 | 500 | 1.2 | 6 | 61 | 35 | 261 | 87 |
| 2 | 40 | M | B | Greater trochanter of the femur | 6 | 3415 | 2170 | 1.5 | 12 | 42 | 67 | 786 | 89 |
| 3 | 27 | F | B | Nonlocalized | 10 | 105 | 216 | 1.7 | 32 | 92 | 187 | 425 | 191 |
| 4 | 27 | F | W | Nonlocalized | 10 | 556 | 370 | 1.8 | 40 | 72 | 62 | 414 | 161 |
All subjects discontinued calcitriol and phosphate 3 days prior to baseline labs.
1,25(OH)2D = 1,25(OH)2 vitamin D; 25(OH)D = 25‐OH vitamin D; B = black; FGF23 = fibroblast growth factor 23; iPTH = intact parathyroid hormone; P1NP = propeptide of type 1 procollagen; TmP/GFR = ratio of the maximum rate of tubular phosphate reabsorption to the glomerular filtration rate; TRP = tubular reabsorption of phosphate; W = white.
a
Gender and age‐specific normal ranges: C‐telopeptide male 31–50 years: 93–630 pg/mL; C‐telopeptide female premenopausal: 25–573 pg/mL; P1NP male: 22–87 μ/L; P1NP female: 19–83 μ/L.