Table 2.
Differences in Gibbs free energy due to missense mutations of SARS‐CoV‐2 S protein
| Gibbs free energy | ||||
|---|---|---|---|---|
| SL No. | Structural domain | Mutation type | Prediction outcome ΔΔG | Structural stability |
| 1. | N‐terminal | T19R | 0.120 kcal mol−1 | Stabilizing |
| 2. | N‐terminal | T95I | 0.257 kcal mol−1 | Stabilizing |
| 3. | N‐terminal | G142D | 1.268 kcal mol−1 | Stabilizing |
| 4. | N‐terminal | R158G | −1.296 kcal mol−1 | Destabilizing |
| 5. | RBD | L452R | −0.533 kcal mol−1 | Destabilizing |
| 6. | RBD | T478K | 0.423 kcal mol−1 | Stabilizing |
| 7. | Hinge region | D614G | 2.330 kcal mol−1 | Stabilizing |
| 8. | Hinge region | P681R | 0.236 kcal mol−1 | Stabilizing |
| 9. | HR1 domain | D950N | 0.064 kcal mol−1 | Stabilizing |
Abbreviations: RBD, receptor‐binding domain; SARS‐CoV‐2, severe acute respiratory syndrome coronavirus 2.