Fig. 8.

Schematic summary of Lrig1- and Wnt-dependent partitioning of MCs and resident immunocytes into distinct epidermal niches. Epidermal niches and their resident cell types in control mice (left), Lrig1 KO mice exhibiting scale IFE fusion (middle) and K14ΔNLef1 mice with MC localization inverted to interscale IFE, resulting in loss of functional segregation of pigmentary units and immune surveillance unit in mouse tail skin (right).