TABLE 2.

Sensitivity and specificity of the Truenat MTB Plus assay and Xpert MTB/RIF assay compared to the reference standard of TB culture^a

Assay and demographic	Total no.	No. true positive	No. false positive	No. false negative	No. true negative	Sensitivity % (95% CI)	Specificity % (95% CI)
Truenat MTB Plus
All participants	945	228	31	23	663	91 (86–94)	96 (94–97)
HIV statusb
HIV positive	352	63	11	11	267	85 (75–92)	96 (93–98)
HIV negative	591	164	20	12	395	93 (88–96)	95 (93–97)
Smear statusc
Smear negative	47	26		21		55 (40–70)
HIV positive	26	15		11		57 (37–76)
Smear positive	204	202		2		99 (96–100)
History of TB
History of TB	135	22	8	2	103	92 (72–99)	93 (86–97)
No history of TB	810	206	23	21	560	91 (86–94)	96 (94–97)
Xpert MTB/RIF
All participants	945	227	10	24	684	90 (86–94)	99 (97–99)
HIV statusb
HIV positive	352	60	5	14	273	81 (70–89)	98 (96–99)
HIV negative	591	166	5	10	410	94 (90–97)	99 (97–100)
Smear statusc
Smear negative	47	25		22		53 (38–68)
HIV positive	26	12		14		46 (27–66)
Smear positive	204	202		2		99 (96–100)
History of TB
History of TB	135	21	4	3	107	88 (67–97)	96 (90–99)
No history of TB	810	206	6	21	577	91 (86–94)	99 (98–100)

^aResults for all participants and by HIV status, smear status (sensitivity), and history of TB, for a total of 945 participants included in the analysis (251 culture positive and 694 culture negative).

^bTwo participants did not have HIV status recorded.

^cAmong people with culture-positive TB.