Table 2.
Main demographic and clinical characteristics of the cohort and univariate analyses of the determinants of humoral response assessed by detectable and protective antibody titres 1 month after each dose of vaccine
| Month 1 | Month 2 | ||||
|---|---|---|---|---|---|
| Protective level of antibodies | Protective level of antibodies | ||||
| Variable | Value | OR (95% CI) | P-value | OR (95% CI) | P-value |
| Age (years), median (IQR) | 71 (61–80) | 1.00 (0.98–1.01) | 0.82 | 0.97 (0.96–0.98) | <0.001 |
| Male gender (%) | 64 | 0.80 (0.50–1.27) | 0.34 | 0.93 (0.68–1.26) | 0.63 |
| HD vintage (years), median (IQR) | 3.3 (1.5–6.7) | 1.00 (1.00–1.00) | 0.25 | 1.00 (1.00–1.00) | 0.63 |
| HDF (%) | 50.5 | 0.75 (0.46–1.21) | 0.23 | 0.79 (0.59–1.06) | 0.11 |
| PMMA membrane (%) | 8.6 | 1.31 (0.66–2.61) | 0.44 | 2.09 (1.13–3.88) | 0.02 |
| Weight (kg), median (IQR) | 75 (64–88) | 1.00 (0.99–1.01) | 0.91 | 1.01 (1.00–1.02) | 0.01 |
| BMI (kg/m2), median (IQR) | 26.6 (23.2–31.0) | 1.00 (0.97–1.04) | 0.81 | 1.02 (0.99–1.04) | 0.12 |
| Smoking (%) | 53 | 0.66 (0.41–1.06) | 0.08 | 1.02 (0.75–1.39) | 0.91 |
| CAD (%) | 34 | 0.95 (0.58–1.55) | 0.84 | 0.78 (0.58–1.06) | 0.12 |
| Hypertension (%) | 85.7 | 1.61 (0.75–3.45) | 0.22 | 0.93 (0.61–1.41) | 0.72 |
| Diabetes (%) | 45.5 | 1.08 (0.68–1.72) | 0.73 | 0.97 (0.72–1.30) | 0.82 |
| PAD (%) | 27.5 | 0.91 (0.54–1.53) | 0.73 | 0.82 (0.59–1.13) | 0.23 |
| Haemopathy (%) | 2.4 | 0.54 (0.07–4.21) | 0.56 | 0.57 (0.22–1.50) | 0.26 |
| Immunosuppressive drugs (%) | 12.2 | 0.71 (0.31–1.61) | 0.41 | 0.43 (0.27–0.68) | <0.001 |
| Transplant (%) | 15.1 | 0.50 (0.23–1.06) | 0.07 | 0.82 (0.55–1.22) | 0.32 |
| Flu vaccine (%) | 60.3 | 1.43 (0.84–2.43) | 0.18 | 1.18 (0.86–1.61) | 0.31 |
| Response to HBV vaccine (%) | 46.1 | 1.16 (0.68–2.00) | 0.58 | 2.02 (1.44–2.84) | <0.001 |
| ACEI (%) | 11.7 | 0.66 (0.29–1.48) | 0.31 | 0.97 (0.61–1.52) | 0.90 |
| ARB (%) | 11.4 | 1.80 (0.92–3.54) | 0.09 | 1.49 (0.91–2.43) | 0.11 |
| VKA (%) | 26 | 0.79 (0.45–1.38) | 0.41 | 0.53 (0.38–0.73) | <0.001 |
| APA (%) | 53 | 1.45 (0.91–2.32) | 0.12 | 0.96 (0.72–1.29) | 0.80 |
| Kt/V, median (IQR) | 1.59 (1.37–1.86) | 0.71 (0.37–1.37) | 0.31 | 0.78 (0.55–1.11) | 0.18 |
| Creatinine (µmol/L), median (IQR) | 585 (470–723) | 1.00 (1.00–1.00) | 0.61 | 1.002 (1.002–1.003) | <0.001 |
| Potassium (mmol/L), median (IQR) | 4.57 (4.18–4.92) | 0.95 (0.63–1.44) | 0.81 | 1.18 (0.90–1.55) | 0.23 |
| Bicarbonate (mmol/L), median (IQR) | 24.3 (23–25.7) | 1.00 (0.92–1.08) | 0.95 | 0.97 (0.92–1.02) | 0.28 |
| Calcium (mmol/L), median (IQR) | 2.21 (2.12–2.30) | 1.38 (0.31–6.19) | 0.68 | 2.44 (0.93–6.41) | 0.07 |
| Phosphate (mmol/L), median (IQR) | 1.43 (1.18–1.73) | 0.65 (0.37–1.14) | 0.14 | 1.38 (0.97–1.97) | 0.08 |
| Total protein (g/L), median (IQR) | 66.7 (62.8–71.0) | 0.98 (0.95–1.02) | 0.31 | 1.04 (1.01–1.06) | 0.004 |
| Serum albumin (g/L), median (IQR) | 38.7 935.0–41.3) | 1.05 (0.99–1.11) | 0.13 | 1.17 (1.13–1.21) | <0.001 |
| CRP (mg/L), mean ± SD | 7 ± 17.3 | 1.00 (0.98–1.01) | 0.65 | 0.98 (0.98–0.99) | <0.001 |
| iPTH (pg/mL), mean ± SD | 331.2 ± 343.5 | 1.00 (1.00–1.00) | 0.37 | 1.00 (1.00–1.00) | 0.67 |
| Hb (g%), mean ± SD | 11.22 ± 1.12 | 1.14 (0.93–1.40) | 0.19 | 1.17 (1.03–1.34) | 0.02 |
| BNT162b2 vaccine (%) | 49 | 0.95 (0.59–1.53) | 0.84 | 0.37 (0.27–0.50) | <0.001 |
OR, odds ratio; CI, confidence interval.