Table 3.
Multivariate analyses of the determinants of humoral response assessed by protective antibody titres 1 month after each dose of vaccine
| Protective level of antibodies | ||||
|---|---|---|---|---|
| Month 1 | Month 2 | |||
| Variable | OR (95% CI) | P-value | OR (95% CI) | P-value |
| Age (years) | 0.97 (0.95–0.99) | 0.008 | ||
| Haemodiafiltration (%) | 1.02 (0.61–1.71) | 0.93 | ||
| PMMA dialysis membrane | 1.03 (0.42–2.55) | 0.94 | ||
| Weight | 1.01 (0.98–1.04) | 0.42 | ||
| BMI (kg/m2) | 0.99 (0.91–1.07) | 0.78 | ||
| Smoking | 0.60 (0.37–0.98) | 0.04 | ||
| CAD | 0.78 (0.48–1.29) | 0.34 | ||
| Immunosuppressive drugs | 1.14 (0.45–2.85) | 0.78 | 0.37 (0.18–0.73) | 0.005 |
| Transplant | 0.41 (0.18–0.92) | 0.03 | 0.62 (0.32–1.18) | 0.15 |
| Response to HBV vaccine | 1.63 (0.99–2.67) | 0.06 | ||
| ARB | 1.75 (0.84–3.65) | 0.13 | 1.48 (0.59–3.71) | 0.40 |
| VKA | 0.48 (0.29–0.79) | 0.005 | ||
| Kt/V | 0.84 (0.43–1.65) | 0.61 | ||
| Creatinine (µmol/L) | 1.00 (1.00–1.00) | 0.76 | ||
| Calcium (mmol/L) | 0.86 (0.15–5.06) | 0.87 | ||
| Phosphate (mmol/L) | 0.61 (0.34–1.12) | 0.11 | 0.84 (0.46–1.55) | 0.58 |
| Total protein (g/L) | 1.05 (1.004–1.094) | 0.03 | ||
| Serum albumin (g/L) | 1.02 (0.96–1.09) | 0.46 | 1.10 (1.05–1.16) | <0.001 |
| CRP (mg/L) | 1.00 (0.98–1.01) | 0.67 | ||
| Haemoglobin (g%) | 1.13 (0.91–1.40) | 0.28 | 1.05 (0.83–1.33) | 0.66 |
| BNT162b2 vaccine (%) | 0.40 (0.24–0.64) | <0.001 | ||
OR, odds ratio; CI, confidence interval.