Table 2.
Obstetric management and maternal/neonatal outcomes in pregnant women with COVID-19
| No intubation (n = 114) | Intubation (n = 73) | p value | |
|---|---|---|---|
| Obstetric management | |||
| Timing of delivery | |||
| Term of delivery (weeks’ gestation) | 37 (34–39) | 31 (28–36) | < 0.001 |
| Delivery before ICU admission, n (%) | 8 (7) | 12 (16) | 0.04 |
| Delivery during ICU stay, n (%) | 23 (20) | 47 (64) | < 0.001 |
| Delivery after ICU discharge, n (%) | 83 (73) | 14 (19) | < 0.001 |
| Indications and modalities of delivery during ICU staya | |||
| Maternal respiratory worsening, n (%) | 16 (70) | 40 (85) | 0.20 |
| Fetal distress, n (%) | 2 (9) | 5 (11) | 1.00 |
| Spontaneous delivery, n (%) | 5 (22) | 2 (4) | 0.03 |
| Cesarean birth, n (%) | 19 (83) | 44 (94) | 0.21 |
| Maternal outcomes and complications | |||
| Mortality, n (%) | 0 (0) | 2 (3) | 0.15 |
| ICU length of stay (days) | 3 (2–5) | 13 (8–27) | < 0.001 |
| Hospital length of stay (days) | 10 (8–16) | 24 (15–40) | < 0.001 |
| Obstetric complications | |||
| Postpartum hemorrhage, n (%) | 5 (4) | 6 (8) | 0.34 |
| Gynecologic infection, n (%) | 2 (2) | 13 (18) | < 0.001 |
| ICU complications | |||
| Pulmonary embolism, n (%) | 3 (3) | 16 (22) | < 0.001 |
| Pneumoniae, n (%) | 20 (18) | 49 (67) | < 0.001 |
| Urinary tract infection, n (%) | 3 (3) | 9 (12) | 0.01 |
| Catheter infection, n (%) | 2 (2) | 5 (7) | 0.11 |
| Severe hemorraghe, n (%) | 1 (1) | 9 (12) | < 0.01 |
| Neonatal outcomes and complications | |||
| Fetal or neonatal mortality, n (%) | 3 (3) | 5 (7) | 0.27 |
| Term of delivery | |||
| Miscarriage < 20 weeks’ gestation, n (%) | 2 (2) | 2 (3) | 0.65 |
| Stillbirth > 20 week’s gestation, n (%) | 1 (1) | 2 (3) | 0.56 |
| Preterm birth (< 32 weeks’ gestation)b, n (%) | 9 (8) | 38 (52) | < 0.001 |
| Preterm birth (< 37 weeks’ gestation)c, n (%) | 25 (22) | 54 (74) | < 0.001 |
| Full-term birth, n (%) | 88 (77) | 19 (26) | < 0.001 |
| Birth’s weight (g) | 3060 (2375–3495) | 1902 (1275–2968) | < 0.001 |
| Small for gestational age, n (%) | 1 (1) | 8 (11) | < 0.01 |
| Organ failure, n (%) | 16 (14) | 28 (38) | < 0.001 |
| ICU admission, n (%) | 21 (19) | 38 (54) | < 0.001 |
| ICU length of stay (days) | 8 (3–17) | 22 (6–44) | 0.09 |
| Hospital length of stay (days) | 6 (3–14) | 41 (8–65) | < 0.001 |
Variables are summarized as median (interquartile range) or number (percentages)
Patients who were intubated < 24 h for fetal extraction only were considered non-intubated
ICU intensive care unit
aAmong patients who were delivered during ICU stay: n = 23 for “no intubation" group and n = 47 for “intubation” group
bPreterm birth at < 32 weeks’ gestation included both live and stillbirths at > 20 weeks’ gestation but < 32 weeks’ gestation
cPreterm birth at < 37 weeks’ gestation included both live and stillbirths at > 20 weeks’ gestation but < 37 weeks’ gestation