In vitro cytotoxic activity of the bergenin derivatives against a panel of cancer and normal cells and the values are represented as IC50 values (μM).

Compound	HCT-15a	CAL-27b	SCC09c	A549d	MCF7e	BEAS-2Bf
5	>100	>100	>100	>100	>100	>100
5a	70.5 ± 9.33	16.03 ± 0.075	32.43 ± 1.78	>100	>100	>100
5b	>100	46.57 ± 1.125	>100	49.89 ± 0.23	37.33 ± 0.19	>100
5c	69.7 ± 0.16	20.71 ± 0.04	34.4 ± 3.03	>100	>100	>100
5d	86.21 ± 4.5	57.2 ± 0.3	65.5 ± 1.75	>100	>100	83.45 ± 6.75
5e	>100	42.7 ± 4.06	>100	40.62 ± 1.545	25.25 ± 0.09	>100
10a	>100	>100	>100	>100	>100	>100
10b	>100	91.23 ± 7.13	64.8 ± 8.715	>100	>100	97.29 ± 14.81
10c	85.94 ± 2.7	30.48 ± 1.16	37.60 ± 8.805	>100	>100	58.55 ± 10.5
10d	30.2 ± 0.64	15.41 ± 0.5	17.41 ± 1.255	22.46 ± 0.06	19.59 ± 0.40	21.73 ± 0.68
10e	97.56 ± 6.3	>100	32.6 ± 9.09	65.61 ± 1.91	64.09 ± 0.47	44.16 ± 8.5
10f	>100	63.72 ± 2.62	91.9 ± 2.6	90.64 ± 0.39	74.54 ± 1.42	>100
10g	>100	81.20 ± 1.065	>100	>100	>100	>100
10h	>100	83.73 ± 7.5	>100	>100	>100	>100
10i	>100	53.03 ± 2.64	>100	>100	>100	>100
13a	>100	56.75 ± 0.46	>100	>100	>100	51.62 ± 6.07
13b	>100	>100	>100	>100	>100	22.4 ± 0.71
13c	>100	>100	>100	>100	>100	>100
13d	>100	85.48 ± 2.97	>100	>100	>100	>100
13e	>100	74 ± 2.65	>100	>100	>100	>100
13f	>100	>100	>100	>100	>100	>100
13g	>100	>100	>100	>100	>100	>100
13h	>100	>100	>100	>100	>100	>100
13i	>100	92.93 ± 1.25	>100	>100	>100	>100
13j	>100	>100	>100	>100	>100	>100
13k	>100	>100	>100	>100	>100	>100
13l	>100	>100	>100	>100	>100	>100
13m	>100	68.6 ± 6	>100	>100	>100	>100
13n	>100	91.56 ± 1.09	>100	>100	>100	>100
13o	>100	41.62 ± 4.59	>100	>100	>100	>100
Doxorubicin	0.8 ± 0.2	0.4 ± 0.1	0.39 ± 0.12	0.8 ± 0.2	1.1 ± 0.13	0.8 ± 1.1

^aColorectal cancer.

^bTongue cancer.

^cOral cancer.

^dBreast cancer.

^eLung cancer.

^fNormal lung epithelial cells.