Table 3.

Solicited Local and Systemic Reactions on the Day After and Anytime Within 7 Days After a Third-Dose BNT162b2 Vaccine in Adults Who Previously Received 2 Doses of Inactivated Coronavirus Disease 2019 Vaccine

Post-Vaccination Reactions	Anytime Within 7 Days After Third-Dose BNT162b2 Vaccine	Day 1 After Third-Dose BNT162b2 Vaccine
	(N = 304)	(N = 304)
	n (%)	n (%)
Local reactions at the injection site
ȃPain	141 (46)	130 (43)
ȃTenderness	133 (44)	108 (36)
ȃSwelling or hardness	71 (23)	51 (17)
ȃItchiness	20 (7)	2 (1)
ȃRedness	15 (5)	5 (2)
Systemic reactions and general symptoms
ȃFeverish	72 (24)	55 (18)
ȃFever ≥38.0°C	25 (8)	20 (7)
ȃChills	32 (11)	29 (10)
ȃHeadache	75 (25)	56 (18)
ȃMyalgia	54 (18)	38 (12)
ȃFatigue	56 (18)	42 (14)
ȃDrowsiness	51 (17)	38 (12)
ȃMalaise	31 (10)	20 (7)
ȃPain at the injection site	25 (8)	14 (5)
ȃLoss of appetite	21 (7)	12 (4)
ȃDizziness	21 (7)	11 (4)
ȃRunny nose	20 (7)	12 (4)
ȃNasal congestion	19 (6)	9 (3)
ȃArthralgia	17 (6)	10 (3)
ȃSneezing	17 (6)	8 (3)
ȃSore throat	17 (6)	10 (3)
ȃChest discomfort	13 (4)	9 (3)
ȃDiarrhea	13 (4)	4 (1)
ȃAbdominal distention	11 (4)	6 (2)
ȃPalpitations	11 (4)	5 (2)
ȃInsomnia	11 (4)	5 (2)
ȃPhlegm	10 (3)	5 (2)
ȃNausea	9 (3)	5 (2)
ȃCough	8 (3)	4 (1)
ȃAbdominal pain	7 (2)	4 (1)
ȃConstipation	6 (2)	4 (1)
ȃBody itching	5 (2)	2 (1)
ȃFlushing of the face	4 (1)	3 (1)
ȃSkin rash	3 (1)	1 (0)
ȃChest pain	3 (1)	0 (0)
ȃEnlarged lymph nodes	3 (1)	0 (0)
ȃFace swelling	2 (1)	0 (0)
ȃArm or leg swelling	1 (0)	1 (0)
ȃMuscle spasms	1 (0)	1 (0)
ȃConfusion	1 (0)	1 (0)
ȃDyspnea	1 (0)	0 (0)
ȃNosebleeds	0 (0)	0 (0)
ȃAgeusia	0 (0)	0 (0)
ȃAnosmia	0 (0)	0 (0)
ȃConjunctivitis	0 (0)	0 (0)
ȃVomiting	0 (0)	0 (0)
ȃFacial drooping/weakness	0 (0)	0 (0)
ȃLoss of consciousness	0 (0)	0 (0)
ȃSeizure	0 (0)	0 (0)

Daily frequencies within 7 days after third-dose BNT162b2 vaccine for selected reactions are shown in Figure 2.