Figure 4.

Angiotensin-converting enzyme 2 (ACE2) binding inhibition toward Omicron is boosted by a third vaccine dose. Changes in ACE2 binding response following the third dose of BNT162b2 for all variants within the study. Samples come from either boosted (n = 20, A), 1–2 months post–second dose of BNT162b2 (n = 20, B), or 5–6 months post–second dose of BNT162b2 (n = 20, C). Individual samples are highlighted by connected lines with bars representing medians. The 20% cutoff for nonresponders is indicated by the dashed line. Abbreviations: ACE2, angiotensin-converting enzyme 2; WT, wild-type.