Table 1.
Maternal Demographic, Clinical Characteristics, Obstetric, and Infectious Outcomes in Pregnant Patients With SARS-CoV-2 Infection
| Characteristic | SARS-CoV-2 Placental Injury, n = 7 (%) | SARS-COV-2 Without Placental Injury, n = 16 (%) |
|---|---|---|
| Demographic | ||
| Maternal age at delivery, mean [SD], years | 27.3 [5.4] | 25 [5.9] |
| Race/Ethnicity | ||
| Non-Hispanic Black | 4 (57) | 11 (69) |
| Non-Hispanic White | 0 | 0 |
| Hispanic | 3 (43) | 5 (31) |
| Medical | ||
| Nulliparous | 3 (43) | 5 (31) |
| Comorbidities | ||
| Asthma | 2 (29) | 4 (25) |
| Diabetes | 0 | 2 (13) |
| Hypertension | 4 (57) | 6 (38) |
| Mental health | 0 | 5 (31) |
| Obesity | 5 (71) | 8 (50) |
| Pregravid Body Mass Index (kg/m2, Missing n = 4) | ||
| BMI 18–24.9 | 0 | 4 (25) |
| BMI 25–29.9 | 3 (43) | 3 (19) |
| BMI 30.0–39.9 kg/m2 | 1 (14) | 6 (38) |
| BMI ≥40 kg/m2 | 2 (29) | 2 (13) |
| SARS-CoV-2 Infection | ||
| Gestational age at infection, median [IQR], weeks | 19 [16–39] | 34 [15–38] |
| Indications for Testing | ||
| Asymptomatic testing | 4 (57) | 8 (50) |
| Person under investigation | 3 (43) | 8 (50) |
| First trimester infection | 1 (14) | 2 (13) |
| Second trimester infection | 4 (57) | 3 (19) |
| Third trimester infection | 2 (29) | 11 (69) |
| COVID-19 Disease Severity | ||
| Asymptomatic/mild | 7 (100) | 13 (81) |
| Moderate | 0 | 3 (19) |
| Severe | 0 | 0 |
| Perinatal Outcomes | ||
| Obstetric | ||
| Gestational age at delivery, median [IQR], weeks | 39 [38–39] | 38 [35–39] |
| Obstetric Complications | ||
| Hypertensive disorder of pregnancy | 4 (57) | 7 (44) |
| Gestational Diabetes | 1 (14) | 2 (13) |
| Fetal growth restriction | 1 (14) | 0 |
| Stillbirth | 0 | 0 |
| Preterm birth | 1 (14) | 5 (31) |
| Mode of Delivery | ||
| Vaginal | 2 (29) | 9 (56) |
| Cesarean | 5 (71) | 7 (44) |
| Neonatal | ||
| Infant birthweight, mean (SD), grams | 3281 (674) | 2950 (432) |
| SARS-CoV-2 Test Result (4 Tested) | ||
| Negative | 1 | 3 |
Abbreviations: BMI, body mass index; COVID-19, coronavirus disease 2019; IQR, interquartile range; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; SD, standard deviation.
NOTE: Indication for cesarean in those with SARS-CoV-2-induced placental injury included nonreassuring fetal heart tones (n = 2), malpresentation (n = 1), labor arrest (n = 1), failed trial of labor after cesarean (n = 1).