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. 2022 Aug 1;13(8):895–920. doi: 10.1039/d2md00081d


	Funapide (5)⁵⁵	Vixotrigine (6)	AZD3161 (7)⁶⁰	8: Merck⁶²
hNa_V1.1 IC₅₀	—	15.2 μM^b^,^d^,⁴⁶	—
hNa_V1.5 IC₅₀	0.084 μM	3.2 μM^b^,^d^,⁴⁶	12.6 μM^b	2.38 μM (K_i)^c^,^e
hNa_V1.7 IC₅₀	0.054 μM	6.1 μM^b^,^d^,⁴⁶	0.079 μM^b^,^g	0.44 μM (K_i)^c^,^e
Free plasma concentration	—	25 nM@1 mg kg⁻¹ (CFA model)⁵⁷	5 μM@23 mg kg⁻¹^h (rat formalin)	0.53 μM@1 mg kg⁻¹^h^,ⁱ (rat PK)
Free plasma concentration	—	6.0, 74 nM@0.5, 5 mg kg⁻¹ (subchronic, CCI model)⁵⁷	5 μM@23 mg kg⁻¹^h (rat formalin)	0.53 μM@1 mg kg⁻¹^h^,ⁱ (rat PK)