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| Target | Target location | Example | Challenges |
|---|---|---|---|
| Opioid | CNS | Morphine | Abuse potential |
| Fentanyl | |||
| Inhibition of prostaglandin synthesis (NSAID) | Peripheral tissue | Aspirin | Limited efficacy |
| Diclofenac | GI and CV adverse effects | ||
| Loxoprofen | |||
| Gabapentinoid (α2δ ligand) | CNS | Gabapentin | CNS adverse effects |
| Pregabalin | |||
| Mirogabalin | |||
| VGSC inhibitor | PNS and CNS | Lidocaine | CNS and CV adverse effects |
| Mexiletine |
