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| Subtype | Gene | TTX sensitivity | Major expression sites |
|---|---|---|---|
| NaV1.1 | SCN1A | Sensitive | PNS, CNS |
| NaV1.2 | SCN2A | Sensitive | CNS |
| NaV1.3 | SCN3A | Sensitive | PNS, CNS (embryonic) |
| NaV1.4 | SCN4A | Sensitive | Skeletal muscle |
| NaV1.5 | SCN5A | Resistant | Cardiac muscle |
| NaV1.6 | SCN8A | Sensitive | PNS, CNS |
| NaV1.7 | SCN9A | Sensitive | PNS |
| NaV1.8 | SCN10A | Resistant | PNS, cardiac muscle |
| NaV1.9 | SCN11A | Resistant | PNS |
