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. 2022 Aug 1;13(8):895–920. doi: 10.1039/d2md00081d

Animal models used in the evaluation of NaV1.7 inhibitors.

Category Model Endpoint Species Ref.
Pain (nociceptive model) Hot plate Nociceptive response (hind paw flinching/licking) induced by noxious thermal stimuli Mouse 77
Heat thermode Nociceptive response (forearm withdrawal) induced by noxious thermal stimuli Rhesus monkey 90
Acetic acid Nociceptive response (abdominal writhing) induced by the intraperitoneal injection of acetic acid Mouse 111
Formalin Nociceptive response (hind paw flinching/licking/lifting) induced by the intraplantar injection of formalin Mouse/rat 69, 70, 77, 80, 84, 85, 86, 90, 101
Capsaicin Nociceptive response (hind paw licking) induced by the intraplantar injection of capsaicin Mouse 86
CFA Mechanical hypersensitivity induced by the intraplantar injection of CFA Rat 57, 68
Thermal hypersensitivity induced by the intraplantar injection of CFA Mouse/rat 61, 82, 112
Cold hypersensitivity induced by the intraplantar injection of CFA Mouse 77, 79
MIA Grip force deficit of hind limbs induced by intra-articular knee injection of MIA Rat 63
Ultraviolet-B (UVB) Thermal hypersensitivity induced by UVB irradiation to the hind paw Mouse 86
Pain (neuropathic model) STZ-induced diabetes Mechanical hypersensitivity induced by diabetic neuropathy Mouse 77
CCI Mechanical hypersensitivity induced by CCI Rat 57
SNL Mechanical hypersensitivity induced by SNL Mouse/rat 48, 61, 62, 67, 68
PSNL Mechanical hypersensitivity induced by PSNL Mouse 48
Thermal hypersensitivity induced by PSNL Mouse 47, 48
Spared nerve injury (SNI) Cold hypersensitivity induced by SNI Mouse 77
Pain (target engagement model) Scorpion toxin OD1 Nociceptive response (hind paw licking/flinching/lifting/shaking) induced by the intraplantar injection of OD1 Mouse 58
Aconitine Nociceptive response (hind paw flinching) induced by the intraplantar injection of aconitine in normal mice Rat 79
IEM-aconitine Nociceptive response (hind paw flinching/licking/biting) induced by the intraplantar injection of aconitine in IEM transgenic mice Mouse 77, 78, 82, 100, 101
Others Itch Scratching behaviour induced by the intradermal injection of histamine into the neck Mouse 83, 85, 86, 99
Cough Coughing response induced by citric acid inhalation Guinea pig 109
Skin blood flow Flare response induced by the topical skin application of capsaicin Mouse 75
Olfactory fMRI Olfaction response (fMRI signal) in OB induced by odour stimulation Rhesus monkey 90