Table 2.
Subgroup analyses of severity of appendicitis and complications
| COVID-19 group (n = 4113) | Control group (n = 4480) | Difference in proportions (%)* | Adjusted P† | |
|---|---|---|---|---|
| Patients treated for complex appendicitis | ||||
| Time interval | ||||
| First 3 months | 672 of 1287 (52.2) | 669 of 1436 (46.6) | 5.6 (1.8, 9.3) | 0.007 |
| Rest of year | 1290 of 2816 (45.8) | 1348 of 3030 (44.5) | 1.3 (−1.3, 3.9) | 0.64 |
| Missing | 10 | 14 | ||
| Age (years) | ||||
| < 6 | 357 of 501 (71.3) | 399 of 590 (67.6) | 3.7 (−1.8, 9.1) | 0.56 |
| 6–12 | 1018 of 2227 (45.7) | 1025 of 2354 (43.5) | 2.2 (−0.7, 5.1) | 0.4 |
| > 12 | 587 of 1375 (42.7) | 593 of 1522 (39.0) | 3.7 (0.1, 7.3) | 0.13 |
| Missing | 10 | 14 | ||
| Region | ||||
| Europe | 1632 of 3406 (47.9) | 1593 of 3585 (44.4) | 3.5 (1.2, 5.8) | 0.02 |
| North America | 136 of 334 (40.7) | 154 of 355 (43.4) | 2.7 (−4.7, 10.0) | >0.99 |
| South America | 22 of 47 (46.8) | 59 of 102 (57.8) | 11.0 (−6.0, 27.3) | 0.63 |
| Africa | 86 of 117 (73.5) | 108 of 157 (68.8) | 4.7 (−6.3, 15.2) | >0.99 |
| Asia | 86 of 199 (43.2) | 103 of 267 (38.6) | 4.6 (−4.4, 13.5) | 0.95 |
| Missing | 10 | 14 | ||
| Subgroup analysis of patients experiencing a complication | ||||
| Time interval | ||||
| First 3 months | 176 of 1291 (13.6) | 173 of 1435 (12.1) | 1.5 (−1.0, 4.0) | 0.48 |
| Rest of year | 302 of 2818 (10.7) | 323 of 3037 (10.6) | 0.1 (−1.5, 1.7) | >0.99 |
| Missing | 4 | 8 | ||
| Age (years) | ||||
| < 6 | 75 of 503 (14.9) | 100 of 589 (17.0) | 2.1 (−2.3, 6.4) | >0.99 |
| 6–12 | 246 of 2230 (11.0) | 252 of 2361 (10.7) | 0.3 (−1.5, 2.1) | >0.99 |
| > 12 | 157 of 1376 (11.4) | 144 of 1522 (9.5) | 1.9 (−0.3, 4.2) | 0.28 |
| Missing | 4 | 8 | ||
| Region | ||||
| Europe | 404 of 3408 (11.9) | 386 of 3592 (10.7) | 1.2 (−0.2, 2.7) | 0.57 |
| North America | 28 of 334 (8.4) | 34 of 354 (9.6) | 1.2 (−3.2, 5.5) | >0.99 |
| South America | 5 of 47 (10.6) | 24 of 102 (23.5) | 12.9 (−1.0, 23.8) | 0.33 |
| Africa | 24 of 121 (19.8) | 32 of 157 (20.4) | 0.6 (−9.1, 9.9) | >0.99 |
| Asia | 17 of 199 (8.5) | 20 of 267 (7.5) | 1.0 (−3.9, 6.4) | >0.99 |
| Missing | 4 | 8 | ||
Values are n (%) unless otherwise indicated; *values in parentheses are 95 per cent confidence intervals. †Chi-Square test, with Bonferroni correction.