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. 2022 Aug 1;76(4):658–666. doi: 10.1093/cid/ciac629

Figure 2.

Figure 2.

Relationship between SARS-CoV-2 live virus neutralization titer and ECLIA by self-LFIA. Positive self-LFIA results are represented in blue and negative LFIA results are represented in red. The threshold of SARS-CoV-2 neutralization detection is defined as ≥7.1, equivalent to 18.5 BAU mL–1, as denoted by the vertical black dotted line and samples below this are marked as not detected (n.d.) Both axes use a Log 10 scale. ECLIA anti-Spike antibody thresholds of ≥100 U mL–1, ≥350 U mL–1, and ≥1000 U mL–1 are denoted by horizontal dotted lines. Statistical significance is reported by performing a non-parametric Mann-Whitney test for neutralization titers by self-LFIA positive and negative results (P = .0001), and for ECLIA anti-Spike antibody titers by self-LFIA positive and negative results (P = .0001). Abbreviations: ECLIA, electrochemiluminescence immunoassay; LFIA, lateral flow immunoassay; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.