Figure 1.

A, Schematic of the process for COVID-19 status assignment. Samples from patients with no record of positive SARS-CoV-2 respiratory testing were only considered negative if corresponding negative respiratory testing occurred on the same day. Due to the lack of a gold standard for active SARS-CoV-2 infection, samples from individuals with history of positive SARS-CoV-2 testing were labeled based on earliest known positive SARS-CoV-2 respiratory test and time since symptom onset. *Samples with postwindow-positive SARS-CoV-2 testing were labeled negative if a negative SARA-CoV-2 test was available following the sample but before the positive test. Otherwise the sample was labeled unknown. B, Flow chart of categorization and labeling process indicating number of samples assigned to each group. Abbreviations: COVID-19, coronavirus disease 2019; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.