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Multivariate analysis of HER2 biomarkers for PFS in 74 patients treated with first-line chemotherapy containing trastuzumab using (A) continuous log2-converted ERBB2 CN and (B) a cutoff value of ERBB2 CN 16. CN, copy number; ERBB2, erb-b2 receptor tyrosine kinase 2; HER2, human epidermal growth factor receptor 2; HR, hazard ratio; IHC, immunohistochemistry; ISH, in situ hybridization; PFS, progression-free survival.
