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. 2022 Aug 17;17(8):e0273080. doi: 10.1371/journal.pone.0273080

Fig 2. Pathway analysis identifies dysregulation of NAD+ metabolism in inflamed UC tissue.

Fig 2

(A) Metabolic pathway (MetPA) analysis of pathways differentially regulated in uninflamed (control + UC) vs inflamed UC colon tissue biopsies, with top significant pathways indicated. (B) NAD+ metabolism pathways, with differentially regulated metabolites color-coded (p<0.05, Mann-Whitney test). (C)–(E) Normalized abundance of (C) NAD+ and its degradation products (D) NAM and (E) ADPr indicated, analyzed by Mann-Whitney test. Graphs depict mean ± SEM. **p<0.01, ***p<0.001. NAD+—Nicotinamide adenine dinucleotide, NAM—Nicotinamide, ADPr–ADP ribose, NA–Nicotinic Acid, NR—nicotinamide riboside, NAMN- nicotinic acid mononucleotide, NAAD—nicotinic acid adenine dinucleotide, NMN—nicotinamide mononucleotide, QA–Quinolinic acid, NMNAT- nicotinamide mononucleotide adenylyltransferase, NAPRT–nicotinate phosphoribosyltransferase, NADS—NAD synthetase, NRK–Nicotinamide riboside kinase, SIRT–Sirtuins, PARP–Poly(ADP-ribose) polymerase, NAMPT—Nicotinamide phosphoribosyltransferase, PncA–Nicotinamidase.