Fig 4. Mitochondrial abnormalities in UC patients.

(A) Representative EM micrographs of colon biopsy tissue from controls and UC patients, with a scale bar of 1 μm. Rectangle indicates region represented in lower panels, with a scale bar of 600 nm. Arrows indicate individual mitochondria. (B-E) Quantitation of the EM micrographs (n = 4 images per sample, 5–8 samples per group) showing changes in (B) the percent area occupied by the mitochondria between groups and (C) the number of mitochondria per 100 μm² area, with no significant changes in (D) single mitochondrial area or (E) the roundness of mitochondria. Graphs depict mean ± SEM, *p<0.05 by Mann-Whitney test. Each point denotes the average of technical replicates for one control/patient.