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. 2022 Aug 3;13:958273. doi: 10.3389/fimmu.2022.958273

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Copyright © 2022 Schulz and Trendelenburg

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Flow diagram of included articles. Flowchart of number of included articles after database query of PubMed and Embase with search terms “complement C1q”, AND “mouse”. Four articles were included based on reference research of cited articles. Articles were initially screened by title and abstract to meet the inclusion criteria (in vivo use of C1qKO mouse, investigated disease model). 177 articles underwent full text review. Thirty-two publications did not fulfill the criteria.